What are PDRN and polynucleotides?
Both are purified fragments of DNA, usually sourced from salmon because its DNA is highly compatible with human tissue. The difference is the size of the fragments: PDRN uses shorter chains, while polynucleotides are longer chains that also form a light, hydrating mesh within the skin.
Once injected, these fragments are thought to support the skin’s own repair and renewal, encouraging healthier collagen and better hydration. The improvement builds gradually over a course of treatments, so it looks natural.
Who is a salmon DNA skin booster for?
- Dull, thin, dehydrated or easily irritated skin
- Early fine lines and crepiness, including under the eyes
- Enlarged pores, uneven texture and mild acne scarring
- Skin that needs help recovering from sun damage
It is not suitable if you are allergic to fish or salmon products, are pregnant or breastfeeding, or have an active skin infection in the area.
Your treatment, step by step
- Free consultation: your doctor examines your skin and recommends PDRN, polynucleotides or a combination.
- Numbing: a numbing cream is applied for comfort.
- Treatment: fine injections are placed across the treatment area, usually taking 20–30 minutes.
- Course: most people have three sessions, two to four weeks apart.
- Maintenance: a top-up every six months or so keeps your skin in good shape.
Results and how long they last
Skin often looks fresher within a week or two of the first session, and texture, firmness and tone continue to improve through the course. Results typically last six months or more, depending on your skin and lifestyle.
Recovery, aftercare and side effects
Small bumps at the injection points usually settle within a day or two. Mild redness, swelling or small bruises are possible. Most people return to normal activities the same day.
- Avoid make-up for 12–24 hours
- Skip saunas, steam rooms and intense exercise for 24–48 hours
- Pause exfoliating acids and retinoids for a few days
- Wear sunscreen every day
Why choose Cutera Aesthetics
- Doctor-led: your salmon DNA skin boosters treatment is assessed, planned and performed by our qualified doctors.
- Free consultation: an honest assessment and a clear plan before you commit to anything.
- A plan made for you: your treatment is tailored to your goals, your skin and your health.
- 12 clinics in 7 cities: Karachi, Lahore, Islamabad, Rawalpindi, Faisalabad, Hyderabad and Sialkot. Find your nearest clinic.
Ready to start? Call or WhatsApp us to book your free consultation, or visit your nearest branch.

















