What are salmon DNA injections and how do they work?
Salmon DNA injections contain purified fragments of DNA, usually taken from salmon because it is highly compatible with human tissue. PDRN (polydeoxyribonucleotide) uses shorter fragments, while polynucleotides are longer chains that also form a light, hydrating mesh in the skin. Placed with very fine needles, they support the skin’s natural repair, helping collagen, hydration and elasticity, so thin or tired skin becomes stronger over a course. Nothing is added to change your shape: the fragments are broken down naturally as the skin renews.
Benefits of salmon DNA injections
- Skin repair: collagen, hydration and elasticity supported from within.
- Gentle on thin skin: suits delicate under-eyes, where fillers can look heavy.
- Smoother texture: rough skin and pores look more refined over the course.
- Calmer skin: sensitive, easily irritated skin feels stronger.
- Natural look: no added volume, so you look fresher, not changed.
- Little downtime: small bumps settle in a day or two; back to work the same day.
Polynucleotides for under-eyes
Under-eye skin is the thinnest on the face, so it creases, darkens and looks tired early. Polynucleotides suit it well: they strengthen and hydrate the skin without adding volume, so there is no puffy or heavy look, and your doctor uses a product made for the eye area. If deep hollows are the main problem, under-eye fillers may suit you better, and dark circles caused by pigment need a dark circle treatment instead.
Salmon DNA before and after
Many people see fresher, brighter skin within one to two weeks of the first session, and texture, firmness and fine lines keep improving through a course of three. In a split-face trial of 27 adults, three polynucleotide injections around the eyes, two weeks apart, improved roughness and pores more than a hyaluronic acid filler on the other side, with no serious side effects. Our patients share their own results in the videos below.
Salmon DNA injection price in Pakistan
Salmon DNA injections cost from Rs 25,000 a session, the same at all 12 of our clinics.
Under-eyes: AMI Eyes
One 2 ml syringe for the delicate under-eye area
Rs 30,000 per session
HYLA, 5 ml
A larger 5 ml treatment
Rs 25,000 per session
Face: AMI Plus or Elaxen
One 2 ml or 2.5 ml syringe
Rs 35,000 per session
Lapuroon, 2 syringes
Two 2.5 ml syringes, for wider areas
Rs 75,000 per session
Free consultation first · Any current offer is explained at the clinic
Who shouldn’t have these injections?
They aren’t suitable if you are allergic to fish or salmon products, during pregnancy or breastfeeding, or with an active skin infection or cold sore in the area. Your doctor checks this at your consultation.
Your salmon DNA treatment, step by step
- Free consultation: your doctor checks your skin and chooses the right product for the area.
- Preparation: cleansing, then numbing cream for comfort.
- Treatment: fine injections across the area, taking 20–30 minutes.
- Course: usually 3 sessions, 2–4 weeks apart.
- Top-up: about every six months to keep results going.
Results and recovery
Small bumps at the injection points settle within a day or two, and mild redness or a small bruise can happen, so most people are back at work the same day. Skin looks fresher within a week or two, texture and firmness keep improving through the course, and results usually last six months or more, depending on your skin and lifestyle.
Aftercare
- No make-up for 12–24 hours
- No gym, sauna or steam for 24–48 hours
- Pause retinol and acids for a few days
- Wear sunscreen every day
Why choose Cutera Aesthetics
- Doctor-led: your treatment is assessed, planned and performed by our qualified doctors.
- Free consultation: an honest assessment and a clear plan before you commit to anything.
- Salmon DNA injections near you: at all 12 clinics in 7 cities, at the same price. Find your nearest clinic.
Sources
- Kim ST, et al. Comparison of polynucleotide and polydeoxyribonucleotide in dermatology: molecular mechanisms and clinical perspectives. Pharmaceutics, 2025; 17: 1024.
- Lee KWA, et al. Polynucleotides in aesthetic medicine: a review of current practices and perceived effectiveness. International Journal of Molecular Sciences, 2024; 25: 8224.
- Lee YJ, Kim HT, et al. Comparison of the effects of polynucleotide and hyaluronic acid fillers on periocular rejuvenation: a randomized, double-blind, split-face trial. Journal of Dermatological Treatment, 2022; 33(1): 254–60.
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